Washington University in St. Louis
Campus Box 1137
One Brookings Drive
St. Louis, MO 63130-4899
DBBS graduate programs Plant and Microbial Biosciences Program
Molecular Microbiology and Microbial Pathogenesis Program
Molecular Cell Biology Program
Research in this laboratory is directed to understanding how plant viruses cause disease and to developing novel strategies to reduce the consequences of virus infection. The three major research topics in the lab include: (1) studies of the molecular stucture and cellular mechanisms that characterize coat protein mediated resistance against tobacco mosaic virus (TMV); (2) the cellular, biochemical, and genetic components that influence cell-cell spread of TMV; and (3) the biochemical activity of host transcription factors that control expression of rice tungro bacilliform badnavirus. Studies in this laboratory encourage students and post-doctoral associates to include computational, biochemical, cellular biology, and genetics in their research.
Photo caption: Accumulation of the tobacco mosaic virus 30 kDa movement protein in BY-2 protoplasts following infection. Fluorescence microscopy was used to visualize MP:GFP fusion protein in association with microtubules and ER.
Beachy, R.N., Heinlein, M. (2000) Role of P30 in replication and spread of TMV. Traffic 1: 540-544.
Qu, C., Liljas, L., Opalka, N., Brugidou, C., Yeager, M., Beachy, R.N., Fauquet, C.M., Johnson, J.E., Lin, T. (2000) 3D domain swapping modulates the stability of members of an icosahedral virus group. Structure Fold Des. 8: 1095-1103.
Pertuccelli, S., Dai, S., Carcamo, R., Yin, Y., Chen, S., Deachy, R.N. (2001) Transcription factor RF2s alters expression of the rice tungro bacilliform virus promoter in transgenic tobacco plants. Proc. Natl. Acad. Sci. USA 98: 7675-7640.
Kotilzky, G., Katz, A., van der Laak, J., Boyko, V., Lapidot, M., Beachy, R.N., Heinlein, M., Epel, B. (2001) A dysfunctional movement protein of tobacco mosaic virus interferes with targeting of wild-type movement protein to microtubules. Mol. Plant-Microbe Interact. 14: 895-904.