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Fall, 2014 | Biology And Biomedical Sciences
Small groups of students take responsibility for their own active learning in their team with guidance from an instructor. Each group in rotation considers four problems of biological importance such as rainforest destruction, coral reefs, laboratory diagnoses, sleep, high altitude, deafness, infertility, modern epidemics, clinical cases, genetic engineering, and cloned animals. They find the background information by library searches and integrate this knowledge in group discussions. Enrollment limited. Intended for but not limited to prospective biology majors. Prerequisite: High school biology, preferably an AP class. For freshmen only.
A lecture course intended for first-year students that focuses on the practice and culture of biological research. Active researchers describe the biological context of their research, the specific questions they have formulated, the means by which they pursue the answers, and their data and conclusions. The focus is on process: how biologists pursue their profession, what goes on in a research setting. Additional topics of clinical and contemporary interest are often included. Students are expected to attend all lectures. Must be taken Credit/No Credit.
An introduction to the breadth and depth of imaging sciences across Arts & Sciences, Medicine and Engineering, on topics from radiology to cell biology. Seminars are presented by experts in these fields to acquaint undergraduate students with advances in imaging sciences and research opportunities in these areas. This seminar is the preferred entry point for freshmen and sophomores for the Imaging Sciences Pathway (http://imagingpathways.wustl.edu/). No prerequisites, primarily for freshmen and sophomores, but open to all students.
A research-based laboratory class for freshmen. Students join a national experiment organized by HHMI, with the goal of isolating and characterizing bacteriophage viruses found in the soil in the St. Louis area. Laboratory work includes isolation and purification of your own phage, DNA isolation and restriction mapping, and EM characterization of your phage. Several WU phage are selected for genome sequencing over winter break, and are annotated in the spring in Bio 192, Phage Bioinformatics. Students who successfully isolate and annotate a phage may become co-authors on a scientific paper. Prereqs: High school courses in biology and chemistry, at least one at the AP or International Baccalaureate level; permission of the instructor, and admission to the Phage Hunters FOCUS program. Limited to 40 students. One hour lecture, one hour discussion, and 3 hrs lab per week.
An introduction to laboratory and field research in biology for first and second year students. Students work under the supervision of a sponsor in a setting of established, ongoing research. Prerequisite: permission of sponsor and the department. For on-line enrollment instructions see: http://www.nslc.wustl.edu/courses/Bio500/bio500.html Students are registered by the department after approval is granted. Registration may not appear in Webstac until mid-semester. Credit/No credit only. Course may not be taken for a letter grade.
Missouri's Natural Heritage is a multidisciplinary two-semester Freshman Focus course. The first semester of the sequence will focus on Missouri geology, climate, archaeology, and native megafauna. This will provide a foundation on which to examine the ecology, restoration, and management of our diverse habitats (prairie, forest, glade, and stream) and the biology of our diverse plant and animal wildlife (arthropods, mollusks, fish, salamanders, lizards, birds, and mammals) in the second semester. We will also introduce basic concepts in biodiversity and resource management with attention to resolution of conflicts of interest. In addition to weekly lecture and discussion, students in this class will visit sites across the state during 3 weekend camping trips and a longer camping trip during winter break. Attendance on field trips is an essential component of the course and grade. Lab fee of $480 covers transportation and meals for all field trips.
Section 1: Earn credit for non-classroom learning in the life sciences in a variety of activities arranged by the student : accompany a WU Faculty physician on rounds and prepare a paper on an organ system or disease, participate in a clinical or applied ecological study and report on it, participate in science outreach teaching, etc. Participants must meet regularly with a supervisor and commit at least 140 hours over two semesters. A work plan is approved prior to registration. A progress report is due after one semester and a final paper after two semesters. Does not count toward the major. Credit: 1.5 units per semester, contingent upon completion of two semesters. See http://www.nslc.wustl.edu/research.html. Credit/No Credit only. Section 3: Conduct a clinical research project with an emergency-medical faculty member. Activities may include screening/enrolling patients, chart reviews, collecting and analyzing data, and clinical shadowing time. Goals include submitting an abstract for a national research meeting and coauthoring a manuscript for publication. Prerequisite: Biol 2652 or Biol 2653. Does not count toward the major. Credit: 1.5 units per semester, contingent upon completion of two semesters. Credit/No Credit only.
MedPrep I (Bio 2651) is a unique lecture series taught by a physician, medical school course master and member of the Committee on Admissions for the School of Medicine. Through a weekly 2-hour lecture, this course gives students accurate, honest, and detailed information regarding every step of the application and admissions process to medical school, the entire educational process including medical school and residency training and pros and cons of life of a physician. MedPrep I is particularly useful for freshman and sophomores in that it reviews the common pitfalls encountered by unsuccessful applicants to medical school and outlines the steps to take in each year of college to be a successful applicant when the time comes. There is no outside course work and no exams. Attendance at all classes is required. A $10 course fee applies. For more information, please see the MedPrep website at pages.wustl.edu/medprep. As of June 30, 2014 registration for MedPrep I will be done through WebSTAC, not through the website.
The Pediatric Emergency Medicine Research Associates Program (PEMRAP) offers undergraduate pre-medical students an opportunity to participate in clinical, patient-oriented research projects in a hospital setting. Students have the opportunity to work in the St. Louis Children's Hospital Emergency Department, a nationally recognized pediatric emergency medicine and trauma care facility. A number of research projects are currently underway in various areas of pediatric emergency medicine. Research Associates are expected to work two 4-hour shifts per week in the St. Louis Children's Hospital Emergency Department and to attend a weekly 2-hour lecture on Mondays in Conference Room 10A of the Northwest Tower Building (across from Children's Hospital) from 12:00 pm - 2:00 pm. Lectures are given by Emergency Department faculty members. This program offers students the unique opportunity to be a vital part of the ED research team. In addition, the RA's experience in the ED may help him/her determine if medicine is truly the career path he/she wishes to choose. May not be taken concurrently with Bio 2654: MEDPREP II. Class size is limited. Enrollment with permission of instructor. Credit/No Credit
MedPrep II (Bio 2654) offers students a real world, behind-the-scenes experience of a life in medicine. For three hours every other week, students shadow physicians in the Charles F. Knight Emergency and Trauma Center of Barnes-Jewish Hospital, the main teaching hospital of the Washington University School of Medicine. In addition to the shadowing, there is a required class session every other Wednesday from 5:30-6:30 pm. Because of the orientation material presented, excused absences will not be granted for the first two sessions for any reason whatsoever, including illness or emergency. There is no outside course work and no exams. A $25 course fee as well as HIPAA training and PPD testing are required. For more information and to register for this course, please see the MedPrep website at pages.wustl.edu/medprep. Registration is done through the website, NOT through WebSTAC. Successful completion of Bio 2651, and sophomore standing or above are required to take Bio 2654. During the summer semester students may take both Bio 2651 and Bio 2654 concurrently.
Introduction to Environmental Biology is designed to teach important principles of environmental biology and general science literacy skills. We cover the foundational biological principles and contemporary issues within four main topics: human population growth, transfer of energy and carbon in the ecosystem, biodiversity, and food production. We focus on the biological principles involved as we examine these topics in the context of some contentious and confusing issues related to environmental biology in everyday life. The science literacy skills that you master in this course will help you address the issues you face in your everyday life regarding scientific and pseudoscientific claims about the environment and society and will form the foundation for your development as a critical consumer of science information in the media. This course is required for all environmental biology majors and the environmental studies minor.
A broad overview of genetics, including Mendelian assortment, linkage, chromosomal aberrations, variations in chromosome number, mutation, developmental genetics, quantitative genetics, population genetics, mechanisms of evolution, and phylogenetics. Three lectures and one laboratory period per week. Does not fulfill the laboratory requirement of the biology major. Prereq: Bio 2960, or permission of instructor. Examination schedule: tests, at which attendance is required, will be given from 6:30-8:30 PM on Tuesday September 23, Thursday October 23, and Thursday November 20.
A survey of human biological diversity, considering its adaptive and taxonomic significance from the perspective of origins and distribution of traits and adaptation. Prerequisite: Anthro 150A or introductory biology.
A lecture/laboratory course designed to provide an integrative framework for how vertebrate form and function evolved. Weekly lectures emphasize development and the relationship between the structural and functional design of organ systems, the importance of these relationships in maintaining homeostasis while providing opportunity for adaptation, and examples of how vertebrate organ systems communicate to accomplish functional and physiological integration. 1.5 hr lecture and 5 hrs lab each week. Prereq: Bio 2970.
An advanced exploration of the structure and function of DNA within the eukaryotic nucleus. Lecture and discussion cover topics of chromatin and chromosome structure, control of gene transcription, RNA processing, and DNA replication and repair. The relevance of these topics to the genetic basis of human disease is discussed. Throughout, the experimental data that shape our current understanding are emphasized. Course grades based on exams, problem sets and short papers. Lecture 3 hours per week plus required discussion section meeting every other week. Prerequisites: Bio 2970, Chem 261 (may be taken concurrently). Offered every other fall in even numbered years.
The basic anatomical, physiological, and chemical organization of the nervous system; how nerve cells communicate with each other, the ionic basis of nerve signals, the function and properties of chemical agents in the nervous system, the development of neural circuitry, and how neurons interact to produce behavior. Prerequisite: Bio 2960, Bio 2970 recommended, Bio 3058 recommended or Psych 3401 and permission of instructor.
Genetic studies of physiological systems underlying animal behavior, including the genetic basis for normal and abnormal behaviors in animals and humans. Topics include: history of behavioral genetics; the ongoing debate about "nature vs. nurture"; contributions of genetic model systems including the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster, zebrafish, the mouse Mus musculus, and other animal models; molecular mechanisms underlying the evolution of behavioral phenotypes; the emerging role of epigenetics in regulating nervous-system functions and behavior; the use of genetic and genomic analyses in studies of human behavior and psychiatric disorders. Prereq: Bio 2970
After introducing students to the basics of bacterial growth and maintenance, this laboratory class employs genetics, cell biology, and genomics to explore various aspects of bacterial physiology, identification, gene structure and mutational analysis of physiological pathways. One hour lecture and five hours of laboratory per week. Fulfills the upper - level laboratory requirement for the Biology major.
A general survey of organic evolution covering both micro and macroevolution. Topics include natural selection, adaptation, evolution of pathogens, formation of species, and phylogenetics. Prerequisite: Bio 2970.
This laboratory course consists of "table-top" experiments in biological physics that are designed to introduce the student to concepts, methods, and biological model systems in biophysics. Most experiments combine experimentation with computer simulations. The list of available experiments includes electrophysiology, human bioelectricity, optical tweezers, ultrasonic imaging, mass spectrometer, and viscosity measurements.Prior completion of Phys 117A, 118A, or Phys 197, 198 or permission of instructor.
This course will review information pertaining both to medications used to treat psychiatric disorders and to psychoactive drugs of abuse. By learning principles of pharmacology and mechanisms of action of these agents, students will develop an enhanced knowledge of the brain mechanisms underlying abnormal human behavior. Enrollment limited to 40. PREREQ: Psych 100B and one of the following: Psych 354 or 3401 or 344 or 3604.
Exceptional undergraduates serve as teaching assistants for laboratory and/or discussion sections in departmental courses. Normally 2 or 3 units are given per semester, subject to the approval of the instructor and the department. Credit may not be counted toward fulfilling the biology major; application form in Department of Biology office. Prerequisite: permission of instructor. Credit /No Credit only.
Neurophysiology is the study of living neurons. Students record electrical activity of cells to learn principles of the nervous system including sensory transduction and coding, intercellular communication and motor control. The course meets for 9 hours each week. Students may leave the lab for up to 2 hours. Prereq: Bio 3411 or Psych 4411 AND PERMISSION of Student Coordinator, Erin Gerrity. Bio 3411 may be taken concurrently.
An introduction to the basic principles of population and ecological genetics. Mechanisms of microevolutionary processes; integrated ecological and genetic approach to study the adaptive nature of the evolutionary process. Prerequisite: Bio 2970.
This course will examine the principles of evolutionary genetics with a focus on applications to current topics in Anthropology such as behavior, life history, adaptation, migration and disease. We will explore human and non-human primate genetic variation in an evolutionary framework and discuss the latest advances in molecular techniques and their applications to addressing fundamental questions in biology. Special topics include kin selection, sexual dimorphism and conservation genetics. Prerequisite: Anthro 150A or introductory biology.
Basic molecular and cellular aspects of the vertebrate Immune System with emphasis upon the interrelationships of non-specific and specific host defense against disease, the nature of immunological specificity and its underlying molecular biology. Includes complement systems, immunochemistry and immunoassay, systems, the nature of cellular activation and effector generation, immunodeficiency, tolerance, tissue transplantation, hypersensitivity, immune regulation and specific diseases illustrative of the successes and failures of the Immune System. Prerequisites: Bio 2970 and Chem 262.
The Immunology Laboratory introduces students to a variety of common, broadly useful immunological techniques and then allows each student to employ most of the learned techniques in addressing a current research question. Experiments employ mouse cells in vitro and emphasize quantitative analysis of the data. Prereq: Bio 424 and permission of instructor.
This course provides investigation-driven research on experimental manipulation of DNA and RNA molecules. This includes the construction, isolation and analysis of plasmids, RNA, PCR products and DNA sequencing. Molecular cloning (genetic engineering), gene knockouts (mutants), RNA isolation, RT-PCR, and microarray projects are performed. Prerequisite: Bio 2960 and Bio 2970. One hour of lecture and eight hours of laboratory each week. This course fulfills the upper-level laboratory requirement for the Biology major. Enrollment is limited to 12. A laboratory fee is required for students who are not full-time Washington University undergraduates.
A study of structure-function relationships as applied to carbohydrates, proteins, and lipids; intermediary metabolism of principal cellular components; and general aspects of regulation. Prereqs: Biol 2970 and Chem 262 OR permission of department. Recommended for students who have achieved grades of B or better in the prerequisites. Students may not receive credit for both Biol 4801 and Biol 451. Not available to students who have credit for Bio 4810 or Bio 4820. Small class.
The goal of this 3-credit laboratory course is to train students in the scientific method. Throughout this course, they study a protein involved in a cellular process. Students, working in small groups, use bioinformatics to identify this protein in a number of species, then use this information to hypothesize which residues of the protein are important for its function. Over the course of the semester, students test their hypotheses in two model systems for studying cellular function-the unicellular eukaryote Saccharomyces cerevisiae and the multicellular eukaryote Physcomitrella patens. The weekly lecture gives students the background necessary to understand and perform their experiments, including information on a variety of bioinformatics tools, phylogeny, protein structure, molecular techniques, cell biology, and microscopy. In addition, students use primary literature to understand the role their assigned protein plays in their cellular process. Enrollment is by permission of instructor. Prereq: Bio 2960 and Bio 2970.
This course examines animal behavior from an evolutionary perspective and explores the relationships between animal behavior, ecology, and evolution. Topics include mating systems, sexual selection, parental care, kin selection, and cooperation. There is a strong active - learning component. Prerequisite: Bio 2970 or permission of instructor.
The first part of a two-semester survey of biochemistry. This course covers biological structures, enzymes, membranes, energy production and an introduction to metabolism. Prerequisites: Biol 2970, Chem 262. Exams at which attendance is required will be given from 6:30 to 8:30pm on Thursday September 25, Tuesday, November 4, and Wednesday December 3.
Photosynthesis is a biological process whereby the Sun's energy is captured and stored by a series of events that convert the pure energy of light into the free energy needed to power life. Respiration is a biological process that extracts energy in a useable form from high-energy compounds produced by photosynthesis. This course examines these essential biological processes at the molecular level in both bacterial and eukaryotic organisms. Emphasis is on chemiosmotic principles as well as the structure and mechanism of action of the protein complexes that carry out photosynthesis and respiration. Additional topics include the assembly and regulation of these protein complexes and the origin and evolution of these processes. Prerequisite: Chem 482, Bio 4820 or Bio 451 or permission of instructor.
Exceptional undergraduates serve as teaching assistants for laboratory and/or discussion sections in departmental courses. Normally 2 or 3 units are given per semester, subject to the approval of the instructor and the department. Credit may not be counted toward fulfilling the biology major; application form in Department of Biology office. Prerequisite: permission of instructor. Credit /No Credit only.
Section 1: In special cases, credit may be given for individual study. Topics of study and credit must be arranged with a faculty sponsor and approved by the Department. Section 2: Molecular Methods in Enzyme Analysis. Understanding enzyme structure and function is essential in many important drug design projects. This course focuses on common methods used to investigate enzyme active sites to elucidate binding interactions between small molecules and enzymes. Students use 3D protein viewing software to design and model modifications to an enzyme active site, then perform those modifications using recombinant DNA technology and site-directed mutagenesis. This course also introduces other commonly used methods to assay active-site metals, characterize inhibitors, over-express and purify proteins, and use UV spectroscopy to analyze enzyme activity. This is an investigative course in which students perform collaborative research projects in small groups. Fulfills the upper-level laboratory requirement for the generic biology major and the biochemistry track; intended for students who have no other courses that fulfill these requirements. (4 credit hours) Prerequisites: Bio2970; Limit 12. Section 3: Social Evolution and Mutualism in the Amoeba Dictyostelium There is a lot more to research than pipetting, or counting cells or weeds. There is more to research than PCR, excellent microscopy skills or careful measurements of any kind. The purpose of this course is to involve undergraduates in the big questions behind their hands-on research. We will read and discuss articles that are foundational for the research questions we ask. We will learn selected statistical techniques and the theory behind statistical analyses using the open source program R. We will learn how to communicate our research outcomes effectively. Please obtain permission from Dr. Strassmann. This course is required for all undergraduates conducting research in the Strassmann/Queller labor
Students work under the supervision of a mentor in a setting of established ongoing research. Prereqs: junior or senior standing and permission of sponsor and the department. Credit to be determined in each case, usually and not exceeding 3 units/semester. Maximum of 6 units may be applied toward upper-level credits required for the major. If work is to be submitted for Honors, see section on senior Honors in the Handbook for Biology Majors. Students expecting to achieve honors in Biology must complete a minimum of 6 units of Bio 500. Registration is best completed prior to the semester for which credit is sought. For detailed information on the Biology Dept's expectations and guidance in finding a mentor, please consult the Bio 200/500 Home Page. For on-line enrollment instructions see: http://www.nslc.wustl.edu/courses/Bio500/bio500.html Students are registered by the department after approval is granted. Registration may not appear Webstac until mid-semester. Credit/No credit only. Course may not be taken for a letter grade.
Study of the human body primarily by dissection; extensive use of X-rays and CT scans. Emphasis on functional and clinical aspects of anatomy. Prerequisite: This course is restricted to first year medical students. If space allows, a small number of graduate students may be permitted to take the course with permission of instructor.
This course applies the fundamental physiological mechanisms of cell biology to the functions of the major organ systems of the body, namely, the cardiovascular, renal, respiratory, gastrointestinal, and endocrine systems. The course is intended primarily for first-year medical students. The Physiology and Microscopic Anatomy courses are closely coordinated within the same schedule. Course continues into the spring semester with a different schedule. Prerequisite, Biol 5061 or the equivalent and permission of course director.
Immunobiology I and II are a series of two courses taught by the faculty members of the Immunology Program. These courses cover in depth modern immunology and are based on Janeway's Immunobiology 8th Edition textbook. In Immunobiology I, the topics include: basic concepts in immunology, innate immunity: the first lines of defense, the induce responses of innate immunity, antigen recognition by B-cell and T-cell receptors, the generation of lymphocyte antigen receptors, antigen presentation to T lymphocytes and signaling through immune system receptors. In Immunobiogy II the topics include: the development and survival of lymphocytes, T cell-mediated immunity, the humoral immune response, dynamics of adaptive immunity, the mucosal immune system, failures of host defense mechanisms, allergy and allergic diseases, autoimmunity and transplantation, and manipulation of the immune response. These courses are open to graduate students. Advanced undergraduate students may take these courses upon permission of the coursemaster. Prereq: DBBS students and advanced undergraduates with permission.
This is a core course for incoming graduate students in Cell and Molecular Biology programs to learn about research and experimental strategies used to dissect molecular mechanisms that underlie cell structure and function, including techniques of protein biochemistry. Enrolling students should have backgrounds in cell biology and biochemistry, such as courses comparable to L41 Biol 334 and L41 Biol 4501. The format is two lectures and one small group discussion section per week. Discussion section focuses on original research articles. Same as M15 5068 and M04 5068.
Journal club in which papers that describe significant advances in the field of experimental hematopoiesis are discussed. Students are expected to present one paper per semester and attend the weekly (1 hour) session. No prerequisites.
Participants (students) present summaries of current research published in various journals in the field of cell biology. A large component of this journal club includes coaching in oral presentation. Students receive one credit for regular participation and for making one presentation.
This journal club covers a broad range of topics related to extracellular matrix and cell-cell communication, including the fields of biochemistry, molecular biology, cell biology, and developmental biology. Speakers give a brief background to introduce the topic and then focus on one paper from the current literature. Presentations are given by students, faculty, and post-doctorates. Students receive 1 unit of credit for regular participation and for making one presentation.
How do ion channels work at the fundamental molecular level? And what do they do for the tissue they are in? How do alterations in channel biology cause myriad diseases - from diabetes to heart attacks, from cystic fibrosis to epilepsy. Students attend journal club each week for 8 weeks and participate in group discussion of recent paper. Once per semester student will choose a paper and present it to the group.
Why do we age? What causes aging? How is our life span determined? This journal club will address such fundamental, but challenging questions of aging and longevity. Recent studies on aging and longevity are now unveiling regulatory mechanisms of the complex biological phenomenon. We'll cover the latest progress in this exciting field and stimulate discussions on a variety of topics including aging-related diseases. One hour of paper presentation and discussion per every two weeks. Prerequisite: Basic knowledge of molecular biology and genetics of model organisms, such as yeast, C. elegans, Drosophila and mouse.
This seminar course consists of a series of tutorial lectures on Imaging Science and Engineering with emphasis on applications of imaging technology. Students are exposed to a variety of imaging applications that vary depending on the semester, but may include multispectral remote sensing, astronomical imaging, microscopic imaging, ultrasound imaging, and tomographic imaging. Guest lecturers come from several parts of the university. This course is required of all students in the Imaging Science and Engineering program; the only requirement is attendance. This course is graded Pass/Fail. Prerequisite: Admission to Imaging Science and Engineering Program.
Principles and Applications of Biological Imaging will introduce the interdisciplinary nature of the imaging sciences and conduct a comprehensive survey of the array of interrelated topics that define biological imaging. The course will cover the basics of the optical, magnetic resonance, CT, SPECT and PET imaging modalities, and microscopy, while focusing on applications of imaging to different disease states, such as oncology, neurology, cardiology and pulmonary diseases. Prereqs. One year each of Biology, Chemistry, Physics and Calculus.
The purpose of the RNA Biology Journal Club is to introduce the graduate students to advanced topics spanning the bioinformatics, biochemistry, cell biology and genetics of RNA biology. Under the guidance of the course directors (Drs. Ory and Schaffer), students will select recent topical articles for discussion in the weekly journal club. Students will be expected to provide a succinct introduction to the topic and lead discussion of the data presented in the journal article. Students will be evaluated on the basis of their presentation and their participation in the seminar throughout the semester. Prerequisites: Successful completion of Fundamentals of Molecular Cell Biology (Bio 5068) and Nucleic Acids and Protein Biosynthesis (Bio 548) or permission of instructors.
Focuses on developing a dialog around current topics in developmental and regenerative biology at the molecular, cellular and systems levels.
Three human disease states will be discussed in detail. Topics will include background clinical and epidemiological information, followed by a detailed examination of the molecular and cellular events that underlie the disease state. Examples of pertinent topics include Alzheimer's disease, AIDS, leukemia, cystic fibrosis, sickle cell anemia, diabetes, etc. Prerequisite: Must be a Markey Pathway student and have HIPAA training.
This journal club covers current papers in molecular oncology, cancer genetics and contemporary molecular biology. Presentations will be given by students, post-docs and faculty, then discussed.
Primarily for graduate and MSTP students, this course involves oral presentation and discussion of current research articles on pathogenic microorganisms (bacteria, fungi, parasites, and viruses) and the cellular and molecular basis of host-pathogen interactions. Emphasis will be placed on understanding methods, critical evaluation of data, and design of future experiments for the articles covered; several sessions will also be devoted specifically to experimental methodology. Students are expected to prepare all articles (including writing a brief future directions paragraph), to participate actively in all discussions, and to each lead several discussions during the semester. Prerequisite: advanced elective course "Molecular Microbiology and Pathogenesis" or permission of instructors.
This journal club will be focused on the Genetics department seminar series. Students will present one or a few recent papers by the seminar speaker scheduled for that week. Students will provide a brief written evaluation (on a form that will be provided) of their peers' presentations, and the faculty advisors will meet with each student after the presentation to provide feedback.
The journal club, which meets weekly, focuses on cellular and molecular biology of the skeleton. Emphasis is placed on gaining insights into normal skeletal homeostasis as well as systemic disorders of bone. Papers presented for review are selected from the most competitive journals. Participants are encouraged to "think outside of the box" and discuss novel molecular discoveries that may impact bone cell function. Prerequisite, permission of instructor.
This course uses a journal club format to discuss contemporary issues in the cell and molecular biology of the immune system. Discussions focus on the use of current approaches to analyze the cellular and molecular basis of immunity. Topics include mechanisms of antigenic specificity, diversity, cell communication, differentiation, activation, and effector activity. Prerequisite, Bio 5051 and permission of instructor.
This journal club considers papers from the current literature on chromatin structure and function, with an emphasis on regulation of transcription, epigenetics and genomics. Presentations are given by students, postdocs and faculty, with discussion by all. Students enrolled for credit are expected to attend regularly, and to present a minimum of one paper during the term, with consultation and critique from the faculty.
This course aims to provide both biologists and those with mathematical backgrounds with a basis in mammalian genetics. The course will include the following modules: Nucleic acid biochemistry; Gene and chromosome organization; Introduction to Human Genetics; Mutations and DNA repair; Cancer Genetics; Genomic methodologies; Biochemical genetics; Murine Genetics; Epigenetics; Neurodegenerative diseases; Mitochondrial disorders; Pharmacogenetics; Introduction to human population genetics; Applications of modern human genetics; Introduction to web-based informatics tools for molecular genetics. One of the required courses in the Quantitative Human Statistical Genetics graduate program.
This journal club covers the recent literature on protein NMR with a focus on using NMR to study protein function, NMR dynamics, and novel methods that expand the range of systems accessible to solution NMR studies. Students, postdocs and faculty discuss a recent paper and present background information on the relevant technical aspects of NMR. Students receive 1 credit for participation and presenting one paper.
Student presentation of molecular biophysics topic. Second year students present from literature; senior students give formal research seminar. Attendance required for all molecular biophysics students.
This course will cover fundamental aspects of biochemistry and cell biology from a medical perspective. The course begins with a treatment of protein structure and the function of proteins in the cytoskeleton and cell motility. The principles of enzyme kinetics and regulation are then discussed and basic pathways for the synthesis and metabolism of carbohydrates and lipids are introduced. This leads in to a discussion of membrane structure and the function cellular organelles in biological processes including energy production, protein degradation and protein trafficking. Prerequisite: Two semesters of organic chemistry. Coursemaster approval is required. Please note: This course is given on the medical school schedule and so it begins 8 days before the grad school schedule.
Multi-laboratory research colloquia for DBBS graduate students focused on structural biology and complementary biophysical techniques. Course credit requires student presentation for credit.
This course covers three major types of biomolecular structure: proteins, nucleic acids and membranes. Basic structural chemistry is presented, as well as biophysical techniques used to probe each type of structure. Selected topics include: protein folding, protein design, x-ray crystallography, NMR spectroscopy, nucleic acid bending and supercoiling, nucleic acid:protein interactions, RNA folding, membrane organization, fluidity, permeability and transport, and membrane channels. Weekly discussion section will cover problem sets and present current research papers. One of the required courses for the Biochemistry and for the Molecular Biophysics graduate programs. Prerequisites; prior coursework in Biochemistry and in Physical Chemistry is recommended, but not required.
Graduate level seminar course focusing on current scientific literature in molecular parasitology. The journal club will meet biweekly during the Fall and Spring semesters. Students will attend both semesters in order to receive one credit. The seminar series will run jointly with a research conference in Tropical and Molecular Parasitology. Outside speakers will be invited for the seminar series to emphasize important developments in tropical medicine and molecular parasitology. In advance of the invited speakers, topics will focus on their previous research publications. Prerequisites, BIO 5392 Molecular Microbiology & Pathogenesis.
This journal club covers a broad range of topics of current interest, including the fields of biochemistry, molecular biology, cell biology, developmental biology, and immunology. Speakers usually give a brief background to introduce the topic and then focus on one-two papers from the current literature. Presentations are given by graduate students, post-doctorates, and faculty. Each attendee presents two-three times per year. Participants are expected to attend all the sessions. It will begin on 9/10 and will end on 12/17. This journal club was founded in 1966.
Special topics course offered every other week involving the discussion of research papers covering a broad range of topics in the field of biochemistry. Papers selected from the primary literature will be presented and discussed by students with guidance from the instructor. Emphasis will be placed on papers that illustrate the application of chemical approaches to important biological processes. Designed primarily for first- and second-year graduate students in the Biochemistry Ph.D. program. Prerequisites: coursemaster permission.
This journal club is intended for beginning graduate students, advanced undergraduates, and MSTP students with a background in the quantitative sciences (engineering, physics, math, chemistry, etc). The subjects covered are inherently multidisciplinary. We will review landmark and recent publications in quantitative cardiovascular physiology, mathematical modeling of physiologic systems and related topics such as chaos theory and nonlinear dynamics of biological systems. Familiarity with calculus, differential equations, and basic engineering/thermodynamic principles is assumed. Weekly meetings to review and discuss current cardiovascular physiology and biophysics journal articles. Prereq.: Calculus, physiology/anatomy is optional.
Fundamental aspects of the structure, biosynthesis, and function of nucleic acids and the biosynthesis of proteins. Emphasis on mechanisms involved in the biosynthetic processes and the regulation thereof. Lecture course supplemented with student discussions of research papers. Prerequisites: Biol 3371, Biol 451, Chem 481 or equivalent, or permission of instructor.
Basic Genetic concepts: meiosis, inheritance, Hardy-Weinberg Equilibrium, Linkage, segregation analysis; Linkage analysis: definition, crossing over, map functions, phase, LOD scores, penetrance, phenocopies, liability classes, multi-point analysis, non-parametric analysis (sibpairs and pedigrees), quantitative trait analysis, determination of power for mendelian and complex trait analysis; Linkage Disequilibrium analyses: allelic association (case control designs and family bases studies), QQ and Manhattan plots, whole genome association analysis; population stratification; Quantitative Trait Analysis: measured genotypes and variance components. Hands-on computer lab experience doing parametric linkage analysis with the program LINKAGE, model free linkage analyses with Genehunter and Merlin, power computations with SLINK, quantitative trait anaylses with SOLAR, LD computations with Haploview and WGAViewer, and family-based and case-control association anaylses with PLINK and SAS. The methods and exercises are coordinated with the lectures and students are expected to understand underlying assumptions and limitations and the basic calculations performed by these computer programs. Auditors will not have access to the computer lab sessions. Prerequisite: M21-515 Fundamentals of Genetic Epidemiology. For details, to register and to receive the required permission of the Coursemaster contact the GEMS Program Manager (firstname.lastname@example.org or telephone 362-1052).
Students will present a research paper (or present their current thesis research) and the appropriate background material.
The course will cover the use of genomic and genetic information in the diagnosis and treatment of disease, with an emphasis on current practice and existing gaps to be filled to achieve precision medicine. Areas of discussion include: bioinformatics methods; assessment of pathogenicity; use and curation of disease variant databases; discovery of incidental findings; genomics applications in Mendelian disease, complex traits, cancer, pharmacogenomics, and infectious disease; design of clinical trials with genetic data; ethical and policy issues. Prerequisites: Genomics (Bio 5488), Advanced Genetics (Bio 5491), or Fundamentals of Mammalian Genetics (Bio 5285) or equivalent (permission from instructor).
In this biweekly journal club on Human Genetics we will present and discuss current cutting edge papers in human and mammalian molecular genetics. Students learn presentation skills, how to critique a paper and how to interact with a very active and critical audience. Prerequisites; Any person interested in the current state of the art in Human Genetics may attend this course. It is a requirement that all students wishing to earn credit in this course must present a 1.5 hour journal club talk and must regularly attend and participate in the journal club throughout the year.
This course focuses on mathematical and algorithmic issues in systems biology and biological sequence analysis. The essential mathematics is introduced first. Systems biology topics include synthetic biology, dynamical systems modeling, mapping and modeling gene regulatory networks, constraint based approaches to predictive modeling of metabolic networks, and the integration of regulatory and metabolic models. Sequence analysis topics include, Hidden Markov Models, parameter inference, sequence alignment, and modeling transcription factor binding sites. This course will include a combination of paper and pencil homework assignments and programming labs. Prereqs: An introductory course in computer programming or equivalent experience and at least two semesters of calculus.
Students present current research papers and the appropriate background material in the field of Computational Biology. **Arts and Sciences students must take this course for credit; Engineering students must take this course Pass/Fail.**
This course will present a fully integrated overview of nerve cell structure, function and development at the molecular and cellular level. Broad topics to be covered include gene structure and regulation in the nervous system, quantitative analysis of voltage- and chemically-gated ion channels, presynaptic and postsynaptic mechanisms of chemical neurotransmission, sensory transduction, neurogenesis and migration, axon guidance and synapse formation. Two lectures plus one hour of discussion per week for 14 weeks. There will be three exams, as well as homework problems and summaries of discussion papers. Prerequisites: graduate standing or permission of the instructor.
Synaptic function and malleability are fundamental to nervous sytem function and disease. This is an advanced seminar in the development, structure, and function of the synapse in health and disease. It is a natural extension of topics covered in Bio 5571. It may be primarily of interest to students in the Neurosciences Program, but also to students in MCB, Development, Biochemistry, Computational Biology, and Molecular Biophysics. Generally a topic for the semester helps focus the group; past topics have included Synapses and Disease, Neurotransmitter Transporters, Glutamate Receptors, Dendrites, GABA receptors. Participants (students, postdocs, and faculty) alternate responsibility for leading critical discussion of a current paper. Active participation offers the opportunity for students to hone their critical thinking and presentation skills. Students enrolling for credit will be expected to attend each week, to lead discussion once per semester and to provide written critiques (1-2 pages each) of two papers. Prerequisites, Graduate standing in DBBS; Bio 5571 preferred.
This course will develop critical thinking and analysis skills with regard to topics in Cognitive, Computational and Systems Neuroscience. Course format will be a series of modules composed of intensive, faculty-led case studies on interdisciplinary topics at the intersection of psychology, computation and neuroscience. The goal will be to highlight the benefits of integrative, interdisciplinary approaches, by delving into a small set of topics from a variety of perspectives, rather than providing a survey-level introduction to a broader set of topic areas. Modules will involve a combination of lectures and student-led discussion groups, with students further expected to complete a multi-disciplinary integrative final review paper. Case-study topics will vary somewhat from year to year, but are likely to include some of the following: temporal coding as a mechanism for information processing, coordinate transformations in sensory-motor integration, mechanisms of cognitive control, motor control strategies including application to neural prosthetics, and memory systems in health and disease. PREREQ: Graduate standing.
Clocksclub focuses on recent advances in the study of biological timing including sleep and circadian rhythms. Participants discuss new publications and data on the molecules, cells and circuits underlying daily rhythms and their synchronization to the local environment. Students registered for this journal club will lead a discussion once during the semester. Prerequisites: BIO 2970 or permission of instructor.
In-depth exploration of landmark and current papers in genetics, molecular and cell biology, with an emphasis on prokaryotes and eukaryotic microbes. Class discussions will center on such key discoveries as the chemical nature of genetic material, the genetic code, oxygen producing light-spectrum, cell-cell signaling, transcriptional regulation, the random nature of mutation, and cell cycle regulation. Emphasis will be placed on what makes a good question or hypothesis, expedient ways to address scientific problems, and creative thinking. The last third of the course will consist of student-run seminars on selected topics to increase proficiency in the synthesis of new material and public presentation skills.
This weekly seminar, covering different topics each semester, should be taken by graduate students in the program. Prerequisite: graduate standing or permission of the instructors.
Students in this journal club will meet weekly with ethnobotanists, ethnozoologists, and ecologists from various St. Louis institutions (including Washington University, UM-St. Louis, St. Louis University, and the Missouri Botanical Garden) to discuss recent publications and ongoing research. Enrolled students will attend the journal club every week, and once per semester, will choose a paper and lead the discussion.
A survey of angiosperm families, their phylogeny, morphology, cytology, anatomy, palynology, chemistry, and evolution. Prerequisite: Bio 4132 or equivalent.
Credit to be arranged.
Credit to be arranged.
Credit to be arranged.
Credit to be arranged.
These seminars cover the recent literature in various areas not included in other courses, or in more depth than other courses. Prerequisite: permission of instructor. Credit to be arranged.
Students serve as teaching assistants for undergraduate and graduate level courses. Faculty-supervised activities include: lecture preparation and presentation; leading discussion and problem-solving sessions; laboratory instruction. Prerequisite: restricted to graduate students in the Division of Biology & Biomedical Sciences.
This course is designed for individual students wishing to explore indepth specialized areas of literature or technology with one or more faculty members. Credit will vary with the amount of work and discussion, but cannot be more than 3 credits.