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Spring, 2015 | Biology And Biomedical Sciences
A research-based laboratory class for freshmen. Students join a national experiment organized by HHMI, with the goal of genomic characterization of a local phage. Laboratory work focuses on learning computer-based tools for genome analysis followed by annotation and comparative analysis of the genome of a phage (bacterial virus) that was isolated fall semester at WU and sequenced over winter break. Prerequisites: High school courses in biology, chemistry, and physics, at least one at the AP or International Baccalaureate level; permission of the instructor. Limited to 40 students; preference given to those completing Bio 191, Phage Hunters. One hour lecture, one hour discussion, and 3 hrs lab per week.
An introduction to laboratory and field research in biology for first and second year students. Students work under the supervision of a sponsor in a setting of established, ongoing research. Prerequisite: permission of sponsor and the department. For on-line enrollment instructions see:http://www.nslc.wustl.edu/courses/Bio500/bio500.html Students are registered by the department after approval is granted. Registration may not appear in Webstac until mid-semester. Credit/No credit only. Course may not be taken for a letter grade.
The National Outdoor Leadership School (NOLS) has developed a comprehensive curriculum to instruct individuals in backcountry first aid. This curriculum will be the main content taught in the course. After successfully completing this detailed 18 hour NOLS Wilderness First Aid course, students will be required to write-up a full assessment and treatment plan (5-7 page minimum) for one of the wilderness casualties described in Peter Stark's Last Breath. Students will meet for a half-day seminar during which each will present their case, assessment, underlying physiology, and treatment plan to the group. They will receive feedback from one another, and from the instructor, about their assessment, explanation of the relevant physiology, and action of their proposed intervention. Prerequisite or Corequisite: NOLS Wilderness First Aid Course (18 hours).
Section 1: Earn credit for non-classroom learning in the life sciences in a variety of activities arranged by the student : accompany a physician on rounds and prepare a paper on an organ system or disease, participate in a clinical or applied ecological study and report on it, participate in science outreach teaching, etc. Participants must meet regularly with a supervisor and commit at least 140 hours over two semesters. A work plan is approved prior to registration. A progress report is due after one semester and a final paper after two semesters. Does not count toward the major. Credit: 1.5 units per semester, contingent upon completion of two semesters. See http://www.nslc.wustl.edu/research.html. Credit/No Credit only. Section 3: Conduct a clinical research project with an emergency-medical faculty member. Activities may include screening/enrolling patients, chart reviews, collecting and analyzing data, and clinical shadowing time. Goals include submitting an abstract for a national research meeting and coauthoring a manuscript for publication. Prerequisite: Biol 2652 or Biol 2654. Does not count toward the major. Credit: 1.5 units per semester, contingent upon completion of two semesters. Credit/No Credit only.
MedPrep I (Bio 2651) is a unique lecture series taught by a physician, medical school course master and member of the Committee on Admissions for the School of Medicine. Through a weekly 2-hour lecture, students receive accurate, honest, and detailed information regarding every step of the application and admissions process to medical school, the entire educational process including medical school and residency training and pros and cons of life of a physician. MedPrep I is particularly useful for freshman and sophomores in that it reviews the common pitfalls encountered by unsuccessful applicants to medical school and outlines the steps to take in each year of college to be a successful applicant when the time comes. There is no outside course work and no exams. Attendance at all classes is required. A $10 course fee applies. For more information go to the MedPrep website at pages.wustl.edu/medprep. Registration for MedPrep I is done through WebSTAC.
The Pediatric Emergency Medicine Research Associates Program (PEMRAP) offers undergraduate pre-medical students an opportunity to participate in clinical, patient-oriented research projects in a hospital setting. Students have the opportunity to work in the St. Louis Children's Hospital Emergency Department, a nationally recognized pediatric emergency medicine and trauma care facility. A number of research projects are currently underway in various areas of pediatric emergency medicine. Research Associates are expected to work two 4-hour shifts per week in the St. Louis Children's Hospital Emergency Department and to attend a weekly 2-hour lecture on Mondays in Conference Room 10A of the Northwest Tower Building (across from Children's Hospital). Fall and Spring lecture sessions are held from 12:00 pm - 2:00 pm. Summer lecture sessions are held from 10:00am - 12:00pm. Lectures are given by Emergency Department faculty members. This program offers students the unique opportunity to be a vital part of the ED research team. In addition, the RA's experience in the ED may help him/her determine if medicine is truly the career path he/she wishes to choose. May not be taken concurrently with Bio 2654: MEDPREP II. Class size is limited. Enrollment with permission of instructor. Credit/No Credit
MedPrep II (Bio 2654) offers students a real world, behind-the-scenes experience of a life in medicine. For three hours every other week, students shadow physicians in the Charles F. Knight Emergency and Trauma Center of Barnes-Jewish Hospital, the main teaching hospital of the Washington University School of Medicine. In addition to the shadowing, there is a required class session every other Wednesday from 5:30-6:30 pm. Because of the orientation material presented, excused absences will not be granted for the first two sessions for any reason whatsoever, including illness or emergency. There is no outside course work and no exams. A $25 course fee as well as HIPAA training and PPD testing are required. For more information and to register for this course, please see the MedPrep website at pages.wustl.edu/medprep. Registration is done through the MedPrep website, NOT through WebSTAC. Successful completion of Bio 2651, and sophomore standing or above are required to take Bio 2654. During the summer semester students may take both Bio 2651 and Bio 2654 concurrently.
This course provides students interested in Health Professions with an overview of Occupational Therapy, Physical Therapy, and Audiology. Students gain a better understanding of the scope of practice, markets, and skills required to succeed in these professions. Students learn about graduate and professional education options and how to build a competitive application for these programs. Finally, students participate in self-directed learning experiences (which may include observations, attending professional presentations, or sitting in on graduate-level classes) and culminate their study with an inter-professional education session illustrating the role of each of the professions within a case study format. Students finish the course with a better understanding of whether a career in health professions is right for them.
The course provides an introduction to biochemistry, cell biology, and molecular biology. An understanding of cellular architecture and mechanism, and the properties of biological macromolecules are integrated with a discussion of the flow of genetic information within cells. The course ends with the application of this understanding to selected areas in modern biology. Weekly labs reinforce concepts from lecture and explore common laboratory techniques and computer-based resources. Prereq: Chem 111A and Chem 112A (concurrently). Examination schedule: Exams will be given from 6:30pm - 8:30pm on the following evenings: Monday, February 16, Monday, March 23, and Monday, April 20. DO NOT SCHEDULE A CONFLICT FOR THESE EVENINGS; NO MAKE-UP TESTS WILL BE GIVEN. Three hours of lecture and 2 hours of lab per week.
A research-based laboratory for those enrolled in Bio 2960, this class provides an opportunity to join a research team with the goal of genomic characterization of a locally isolated phage (a virus that infects a bacterial host). Similar to Bio 192, but using a condensed format and a larger team to tackle each phage. Lab work focuses on learning computer-based tools for genome analysis, followed by careful annotation of several genes from your phage and in-depth investigation of one gene. Requires concurrent enrollment in Bio 2960 Principles of Biology I; not open to students enrolled in Bio 192. One 2-hr pre-class online review/preparation session, nine 2-hr laboratory sessions, and a final poster presentation. (Lab does not meet in weeks with a scheduled Bio 2960 midterm.) May be taken for a letter grade or Credit/No Credit.
How did Elvis, Jimmi Hendrix, John Lennon and Michael Jackson die? How have David Letterman and Dick Cheney survived? In this course we work towards understanding the biology behind human health, disease, and disaster. We examine cases from the news, literature and history and work like detectives to understand what happened. We also work at distinguishing honest science and medicine from junk science and scams. This course is designed for students who do not plan to major in science. Therefore, no prior science background is expected. Prerequisite: Sophomore standing or permission of instructor. A student may not receive credit for both Bio 303A and Bio 100A, 2960, 2970.
A 4 credit lecture course that provides an introduction to plant development, genetics, physiology and biochemistry with emphasis on processes that can be manipulated or better understood through genetic engineering. The course is divided into 3 sections. The first section of the course discusses basic plant biology, development and genetics. The second part of the course emphasizes gene structure, expression, and cloning as well as methods for introducing foreign DNA into plant cells and regenerating fertile plants in tissue culture. During the third part of the course we discuss a variety of examples of genetically engineered traits, including: herbicide resistance; fruit ripening; pathogen and/or insect resistance; the use of plants for production of industrial and pharmaceutical compounds. Friday discussion sections focus on critical reading of the primary literature related to the material covered in lecture. Prerequisites: Bio 2960 and Bio 2970.
Systems physiology with emphasis on human physiology. Examination Schedule: Tests, at which attendance is required, will be given from 6:00 - 7:00 p.m. on the following Thursdays: February 12, March 19, and April 16. No makeup exams will be given. Therefore, do not schedule any conflict for the evenings of the exams. Prereqs: Bio 2960 and Chem 112A. Must be taken for a letter grade.
An overview of mammalian endocrine systems with an emphasis on human physiology and development. The interplay between systemic, local cell, and tissue interactions as well as the cell and molecular events associated with hormone action discussed. Examples of endocrine evolution and pathological conditions related to endocrine imbalances also included. Prerequisite: Bio 2970.
This course is designed to provide students with an understanding of the function, regulation, and integration of the major organ systems of the body. Course content includes neural and hormonal homeostatic mechanisms, and study of the circulatory, respiratory, digestive, urinary, musculoskeletal, nervous, endocrine, immune and reproductive organ systems. Mechanisms of exercise physiology are integrated throughout the course. This course is limited to students of Junior or Senior status only. Prerequisites: Bio 3058, or equivalent.
Eukaryotic cell structure and function viewed from the perspective of modern cell biology. Lectures cover such topics as membrane transport, endocytosis and secretion, intracellular trafficking, hormones and signal transduction, extracellular matrix and tissue formation, cytoskeleton and motility, cell cycle, apoptosis, and the cellular basis of disease. Prerequisite: Bio 2970.
This four - credit lecture course focuses on the molecular biology of bacteria, archaea, and viruses. Topics include: the bacterial cell cycle, gene regulation, stress response, cell-cell communication, viral and bacterial pathogenesis, microbial ecology, and metabolic diversity. Friday tutorials stress analysis of the primary literature with an emphasis on current research related to material covered in lecture. Prerequisites: Biology 2960, and 2970, or permission of instructor.
After introducing students to the basics of bacterial growth and maintenance, this laboratory class employs genetics, cell biology, and genomics to explore various aspects of bacterial physiology, identification, gene structure and mutational analysis of physiological pathways. One hour lecture and five hours of laboratory per week. Fulfills the upper-level laboratory requirement for the Biology major. Prerequisite: Bio 2970, Bio 349 recommended.
This research-intensive course provides an introduction to diverse molecular and cytological techniques used in model experimental organisms to explore fundamental biological questions. Experiments are performed using selected fungi and protozoans commonly used in major research efforts. Emphasis is placed on choosing the appropriate organism for the question posed using the most current technologies. Each student selects an uncharacterized gene to study in detail, conducting an original research project. Writing assignments model the components of scientific articles. The final project is a poster presentation of each student's results at the undergraduate research symposium. Prerequisites: Bio 2960 and 2970 and permission of instructor-- contact instructor early to ensure enrollment. One hour of lecture and six hours of laboratory a week. Fulfills the upper-level laboratory requirement for the Biology major and is writing intensive. Enrollment limited to 16.
This course explores the science of ecology, including factors that control the distribution and population dynamics of organisms, structure and function of biological communities, principles that govern ecological responses to global climate change and habitat fragmentation, and experimental design. The class format includes lecture and small group activities and discussions. Assignments include reading, problem sets, and computer lab activities. Prerequisite: Bio 2970 or Bio 2950 or permission of instructor.
Exceptional undergraduates serve as teaching assistants for laboratory and/or discussion sections in departmental courses. Normally 2 or 3 units are given per semester, subject to the approval of the instructor and the department. Credit may not be counted toward fulfilling the biology major; application form in Department of Biology Student Affairs office. Prerequisite: permission of instructor. Credit /No Credit only.
This course will provide students who are interested in research in environmental biology with a broad overview of the skills and tools needed for a successful field-based research. Topics covered will include: (1) developing ideas and approaches for research projects, (2) experimental design and analyses, (3) using the primary literature effectively, (4) writing successful small grant and fellowship proposals, and (5) writing/reporting results. In addition, students will be exposed to basic field methods, practical skills for organizing and executing research, and how to cope with rough field conditions. Some Saturday and night-time field trips are required. Grading will be based primarily on class participation and take-home assignments. Pre/co-requisites: Permission of Professor Knight and at least one of the following courses: EnSt 370, EnSt 373, Bio 2950, Bio 3501, Biol 372, Bio/EnSt 381, Bio/EnSt 4170, Bio/EnSt 419, Biol 4191, Bio/EnSt 4193.
This course is designed to introduce graduate students and upper-division undergraduates to contemporary approaches and paradigms in plant and microbial biology. The course includes lectures, in-class discussions of primary literature and hands-on exploration of computational genomic and phylogenetic tools. Evaluations include short papers, quizzes, and oral presentations. Over the semester, each student works on conceptualizing and writing a short NIH-format research proposal. Particular emphasis is given to the articulation of specific aims and the design of experiments to test these aims, using the approaches taught in class. Students provide feedback to their classmates on their oral presentations and on their specific aims in a review panel. Prereq: Bio 2970 or permission of the instructor.
Biological clocks are the endogenous oscillators that coordinate physiological and behavioral rhythms in nearly all organisms. This course examines how these rhythms are generated and regulated. The material includes molecular, cellular and systems physiology and the relevance of biological timing to ecology and health in everything from protozoans to plants to people.
A rigorous introduction to the study of evolution at the molecular level. Topics include the origin, amount, distribution and significance of molecular genetic variation within species, and use of molecular data in systematics and in testing macroevolutionary hypotheses. Prerequisite: Bio 2970, or permission of instructor.
Community ecology is an interdisciplinary field that bridges concepts in biodiversity science, biogeography, evolution and conservation. This course provides an introduction to the study of pattern and process in ecological communities with an emphasis on theoretical, statistical and experimental approaches. Topics include: ecological and evolutionary processes that create and maintain patterns of biodiversity; biodiversity and ecosystem function; island biogeography, metacommunity dynamics, niche and neutral theory; species interactions (competition, predation, food webs), species coexistence and environmental change. The class format includes lectures, discussions, and computer labs focused on analysis, modeling and presentation of ecological data using the statistical program R. Prereq: Bio 2970 required, Bio 381 recommended, or permission of instructor.
The goal of this course is to provide skills in the design, interpretation, and written presentation of results of ecological experiments, with emphasis on hypothesis testing, sampling methodology, and data analysis. Students have opportunities to address a variety of ecological questions using field, greenhouse, or laboratory (microcosm) studies. The course is divided into a 5-hour lab period (generally held at the Tyson Research Station) and a 1.5-hour lecture/discussion period held on campus. Occasional Saturday field trips to local sites (e.g., forests, wetlands, prairies, streams) for in-depth study might be scheduled. This is a writing intensive course and grades are based on written assignments, including final projects, and in-class participation. This course fulfills the upper-level laboratory requirement for the Biology major. Prereq: Permission of instructor and at least one of the following: Bio 381, Bio 372, Bio 370, Bio 4170, Bio 4172), or Bio 3501. Credit will not be awarded for both 4191 and 4193. Enrollment is limited to 15 students. 4 units.
Basic molecular and cellular aspects of the vertebrate Immune System with emphasis upon the interrelationships of non-specific and specific host defense against disease, the nature of immunological specificity and its underlying molecular biology. Includes complement systems, immunochemistry and immunoassay, the nature of cellular activation and effector generation, immunodeficiency, tolerance, tissue transplantation, hypersensitivity, immune regulation and specific diseases illustrative of the successes and failures of the Immune System. Prerequisites: Bio 2970 and Chem 252. Interested Juniors in their second semester are particularly encouraged to register for this course. Juniors wishing to take the course but who find themselves waitlisted should contact the instructor.
The Immunology Laboratory introduces students to a variety of common, broadly useful immunological techniques and then allows each student to employ most of the learned techniques in addressing a current research question. Experiments employ mouse cells in vitro and emphasize quantitative analysis of the data. Prereq: Bio 424 and permission of instructor.
Groups of 5-8 students are presented with medical case studies that are then researched and discussed under faculty guidance. Students take major responsibility for their own learning within their team. Enrollment limited to 30 students. Prerequisite: Bio 2970; some experience in molecular biology. A biology or science background is required.
Algae are ubiquitous and highly diverse photosynthetic organisms: they are prokaryotic (cyanobacteria) and eukaryotic, unicellular and multicellular, and central to soil, fresh water, and marine ecosystems. This course considers their molecular taxonomy and evolution, specific lineage adaptations (e.g. silicon in diatoms), life cycles, cell cycle and cell-division mechanisms, light and nutrient acquisition, storage products, cell and cell-wall organization, ecological habitats and symbioses (e.g. lichens), and commercial applications (e.g. carotene, omega-3 fatty acids and other nutraceuticals; biodiesel). A course for upper-level biology and bioengineering undergraduates and graduate students. Tu Th 2:00 - 4:00 until spring break, where a second course, Bio 4830, is highly recommended as a sequel. Assigned readings of research literature pertaining to each lecture topic; final project focused on a student's particular interest. Prerequisite: Bio 334 or Bio 4810 or instructor's permission. Note: Since this is a short course, please email the instructor if you wish to drop the course.
A collaborative laboratory investigation of a problem in comparative genomics, utilizing a variety of bioinformatics tools to manage and investigate large data sets (currently including genomic sequences, gene predictions, sequence conservation, gene expression). In spring '15 the research problem involves improving the sequence of a region of the Drosophila biarmipes or Drosophila elegans genome, and working with one of these sequences to examine patterns of genome organization, gene structure and gene regulation. Class will meet at the WU Genome Institute during the first third of the semester, and in the Biology Department the remainder of the semester. Prerequisites: Bio 297A, Chemistry 111/112, 151/152. While Bio 3371 or Bio 437, and some familiarity with computers would be advantageous, this is NOT required. Permission of Dr. Sarah Elgin is required. Fulfills the upper-level laboratory requirement for the Biology major.
Content equivalent to Bio 4342. Students electing the writing option are required to revise each of three papers (on finishing of their config; gene finding in a human/chimp comparison; and annotating their config at least once, more if needed.
The majority of the laboratory work focuses on a research question using biochemical methods. The course consists of three sections: protein biochemistry, mass spectrometry, and structural biology. In the first section of the course, students learn principles and methods for heterologous expression of proteins in bacteria, protein quantitation, protein purification, SDS-PAGE, and kinetic analysis of enzyme activity. The second part focuses on using mass spectrometry to identify and to characterize proteins. The final part of the course introduces students to concepts of structural biology including protein crystallization, x-ray diffraction, and computer modeling of protein structures. Fulfills the upper-level laboratory requirement for the Biology major. Prerequisites: Chem 252 and either Bio 451 or Bio 4810/Chem 481. Suggested to be taken concurrently with Bio4820/Chem482.
Topics include carbohydrate, lipid and amino acid metabolism, signal transduction, transport across membranes, DNA replication and repair, transcription and translation, molecular motors, mechanisms of drug action, and the biosynthesis of natural products, biofuels, and biomaterials. Prereq: Bio 2970 and Chem 262. Not available to students who have credit for Bio 451.
A broad overview of the flow of energy, captured from sunlight during photosynthesis, in biological systems, and current approaches to utilize the metabolic potentials of microbes and plants to produce biofuels and other valuable chemical products. An overall emphasis is placed on the use of large-scale genomic, transcriptomic and metabolomic datasets in biochemistry. The topics covered include photosynthesis, central metabolism, structure and degradation of plant lignocellulose, and microbial production of liquid alcohol, biodiesel, hydrogen & other advanced fuels. Course meets during the second half of the spring semester. Prereqs: Biol 4810 or permission of instructor.
Exceptional undergraduates serve as teaching assistants for laboratory and/or discussion sections in departmental courses. Normally 2 or 3 units are given per semester, subject to the approval of the instructor and the department. Credit may not be counted toward fulfilling the biology major; application form in Department of Biology Student Affairs office. Prerequisite: permission of instructor. Credit /No Credit only.
Section 1: In special cases, credit may be given for individual study. Topics of study and credit must be arranged with a faculty sponsor and approved by the Department. Section 3: Social Evolution and Mutualism in the Amoeba Dictyostelium There is a lot more to research than pipetting, or counting cells or weeds. There is more to research than PCR, excellent microscopy skills or careful measurements of any kind. The purpose of this course is to involve undergraduates in the big questions behind their hands-on research. We read and discuss articles that are foundational for the research questions we ask. We learn selected statistical techniques and the theory behind statistical analyses using the open source program R. We learn how to communicate our research outcomes effectively. Please obtain permission from Dr. Strassmann. This course is required for all undergraduates conducting research in the Strassmann/Queller laboratories, and is available to students accepted to conduct future research. 1 unit.
Recent biomedical discoveries have been greatly advanced through the development of innovative, state-of-the-art techniques. For example, Nuclear Magnetic Resonance (NMR) has proved to be an invaluable tool in both efforts to determine the atomic structure of proteins and small molecules as well as in clinical settings, as MRI to identify tumors that would otherwise go unnoticed. This course introduces students to a variety of cutting-edge laboratory techniques, and discusses the impact of these techniques on biology and medicine. Students have the unique opportunity to learn from graduate students employing these approaches in their doctoral studies. Topics include: high-throughput sequencing of genetic disorders, x-ray crystallography, and single molecule force spectroscopy by AFM. Weekly classes consist of a 30-45 minute presentation on a particular technique, followed by 60-minute discussion of the assigned readings. Prerequisites: Biology 2960 and 2970 and at least one semester of BIO500 or equivalent research experience approved by the course master.
Students work under the supervision of a mentor in a setting of established ongoing research. Prereqs: junior or senior standing and permission of sponsor and the department. Credit to be determined in each case, usually 3 units/semester. Maximum of 6 units may be applied toward upper-level credits required for the major. If work is to be submitted for Honors, see section on senior Honors in the Handbook for Biology Majors. Students expecting to achieve honors in Biology must complete a minimum of 6 units of Bio 500. Registration is best completed prior to the semester for which credit is sought. For detailed information on the Biology Dept's expectations and guidance in finding a mentor, please consult the Bio 200/500 Home Page. For on-line enrollment instructions see: http://www.nslc.wustl.edu/courses/Bio500/bio500.html Students are registered by the department after approval is granted. Registration may not appear Webstac until mid-semester. Credit/No credit only. Course may not be taken for a letter grade.
Exploration of ethical issues which research scientists encounter in their professional activities. Topics will include, but are not limited to: student-mentor relationships, allegations of fraud, collaborators' rights and responsibilities, conflicts of interest, confidentiality, publications. Case study and scenario presentations will provide focus for discussions. Prerequisite, open to DBBS graduate students engaged in research. Six 90 minute sessions.
Late one Friday afternoon in April 1976, the late venture capitalist Robert Swanson met with biochemist Herb Boyer, PhD, at his UCSF lab. Swanson had requested 10 minutes of Boyer's time; when the meeting ended, three hours later, the foundations had been laid for the formation of Genentech, the first biotechnology company, and the beginnings of the biotechnology industry. This course, The Basics of Bio-Entrepreneurship, investigates issues and choices that inventor/scientists encounter when considering the applications and commercialization of early stage scientific discoveries. This course is intended for anyone interested in working in the medical device, life-, bio-, or pharma-sciences industries as a founder, scientist, entrepreneur, manager, consultant, or investor. It focuses on the decision processes and issues that researchers and their business partners face when considering how a discovery might best be moved from academia to successful commercialization.
Immunobiology is a continuation of Immunobiology I (Bio 5053) taught by the faculty members of the Immunology Program and consists of two sections. In the first section, selected topics are covered in depth that were introduced in Immunobiology I. These include cytokine signaling, DC subsets, tumor immunology, evolution of the immune response, Fc Receptors, alloreactivity, mucosal immunity, inhibitory receptors, vaccines, lymphoorganogenesis and immunopathogenesis. The second section involves Molecular mechanisms of disease (formerly Bio 5261) and will cover human diseases that appear to have an immunological basis. In addition to lectures and evaluation of recent clinical and relevant basic immunology literature, an emphasis will be placed on direct encounters with patients and pathologic material when feasible, providing students with a human aspect to discussions of immune pathogenesis. Diseases covered will include rheumatoid arthritis, allergy, lupus, multiple sclerosis, diabetes, immunodeficiencies, complement diseases and hemophagocytic lymphohistiocytosis. Prereq: DBBS students and Immunobiology I.
Journal club in which papers that describe significant advances in the field of experimental hematopoiesis are discussed. Students are expected to present one paper per semester and attend the weekly (1 hour) session. No prerequisites.
This journal club covers a broad range of topics of current interest, including the fields of biochemistry, molecular biology, cell biology, and developmental biology. Speakers give a brief background to introduce the topic and then focus on one-two papers from the current literature. Presentations are given by students, faculty and post-doctorates. Students receive one credit for regular participation and for making one presentation.
Weekly presentations of recent papers on mechanisms of ion channel function and membrane excitability, as well as the role of channel defects in human and model diseases, with lively group discussions the norm! Once per semester, each participant will choose a paper and present it to the group.
Why do we age? What causes aging? How is our life span determined? This new journal club will address such fundamental, but challenging questions of aging and longevity. Recent studies on aging and longevity are now unveiling regulatory mechanisms of the complex biological phenomenon. We'll cover the latest progress in this exciting field and stimulate discussions on a variety of topics including aging-related diseases. One hour of paper presentation or research talk and discussion per every two weeks. Prerequisite: Basic knowledge of molecular biology and genetics of model organisms, such as yeast, C. elegans, Drosophila and mouse. Registered students are expected to have at least one presentation for 1 unit credit.
The purpose of the Metabolism Journal Club is to introduce the graduate students to advanced topics spanning the biochemistry, cell biology and genetics of cellular and whole body metabolism. Under the guidance of the course directors (Drs. Ory and Schaffer), students will select recent topical articles for discussion in the weekly journal club. Students will be expected to provide a succinct introduction to the topic and lead discussion of the data presented in the journal article. Students will be evaluated on the basis of their presentation and their participation in the seminar throughout the semester. Prerequisites: Successful completion of Fundamentals of Molecular Cell Biology (Bio 5068) and Nucleic Acids and Protein Biosynthesis (Bio 548).
Focuses on developing a dialog around current topics in developmental and regenerative biology at the molecular, cellular and systems levels.
An introduction to basic concepts in immunology and immunopathology. Lectures focus on antigen-antibody interactions, immunoglobulin structure and genetics, the cellular basis of the immune response and immune regulation, T cell effector mechanisms, the inflammatory response, complement, the positive and negative roles of hypersensitivity, and immune deficiency. Prerequisite, some background in biochemistry and genetics helpful. Restricted to medical students only except in unusual circumstances, with permission of coursemaster. Offered during the first half of the second medical semester. Three-four lecture hours a week, two 2-hour lab periods, four 1-hour clinical discussion groups.
This journal club covers current papers in molecular oncology, cancer genetics and contemporary molecular biology. Presentations will be given by students, post-docs and faculty, then discussed.
This course is designed to present pre- and postdoctoral trainees with an organized educational format to explore major contemporary topics in cancer biology. The elective will provide an integrated view of cancer research including basic science, translational science, and clinical investigation. Approximately 60 minutes will be devoted to a didactic presentation by a faculty member with interaction by the participants. The remaining 30 minutes will be used to discuss a pivotal research paper from this field, preselected by the faculty member. Outside reading (30-60 min/week) will be required.
Primarily for graduate and MSTP students, this course is centered on critical evaluation of current scientific literature, which is used as a basis for discussion and grant writing, supplemented with sessions on experimental methodology. Paper discussions will involve oral presentation and discussion of current research articles on pathogenic microorganisms (bacteria, fungi, parasites, and viruses) and the cellular and molecular basis of host-pathogen interactions. Emphasis will be placed on understanding methods, critical evaluation of data, and design of future experiments for the articles covered. Students are expected to prepare all articles, to participate actively in all discussions, and to lead one or more discussions during the semester. The grant writing aspect of the course will focus on defining identifying key unanswered questions from the literature, formulating hypotheses for testing, defining Specific Aims, and developing a research plan. Students will submit specific aims based on current literature, receive critiques from faculty members, and develop a NIH-style proposal to investigate them. Students will participate in class discussions and a mock study section to evaluate proposals. Prerequisite, completion of the MMMP advanced elective, Bio 5392 Molecular Microbiology & Pathogenesis or permission of the coursemaster.
This course will introduce Ph.D. and MSTP students to fundamental problems in cell and molecular biology at the systems level. The course is divided into 5 themes: 1) microbial systems; 2) organ development and repair; 3) cardiovascular system and disease; 4) tumor & host systems; and 5) metabolic systems and disease. Topics within each theme highlight current research concepts, questions, approaches and findings at the molecular, cellular and physiological levels. Students will write an original research grant proposal on a topic of their choosing in one of the 5 themes. Students will critique proposals anonymously in an NIH-like study section. Prereqs; Fundamentals of Molecular Cell Biology and Nucleic Acids and Protein Synthesis.
This journal club will be focused on the Genetics department seminar series. Students will present one or a few recent papers by the seminar speaker scheduled for that week. Students will provide a brief written evaluation (on a form that will be provided) of their peers' presentations, and the faculty advisors will meet with each student after the presentation to provide feedback.
The journal club, which meets weekly, focuses on cellular and molecular biology of the skeleton. Emphasis is placed on gaining insights into normal skeletal homeostasis as well as systemic disorders of bone. Papers presented for review are selected from the most competitive journals. Participants are encouraged to "think outside of the box" and discuss novel molecular discoveries that may impact bone cell function.
This journal club considers papers from the current literature on chromatin structure and function, with an emphasis on regulation of transcription, epigenetics and genomics. Presentations are given by students, postdocs and faculty, with discussion by all. Students enrolled for credit are expected to attend regularly, and to present a minimum of one paper during the term, with consultation and critique from the faculty.
A special topics course with lectures and discussion on the molecular basis of cancer including cell cycle regulation, tumor suppressor genes, tumor invasion, angiogenesis, immune evasion, resistance to apoptosis, signaling, imaging, gene expression, chromosomal translocations, and viral oncology.
This course will provide a background in the theory of the dynamics of mesoscopic systems and introduction to methods for measuring the dynamics of these systems. It will include measurement methods, some of which are in common use and others that have only recently been introduced. This course would be useful for biophysics students and others that are interested in molecular processes and mechanisms in small systems such as cells. Prerequisites, Physical Chemistry.
This course will cover equilibria, kinetics and mechanisms of macromolecular interactions from a quantitative perspective. Thermodynamics, multiple binding equilibria (binding polynomials), linkage phenomena, cooperativity, allostery, macromolecular assembly, enzyme catalysis and mechanism, steady-state and pre-steady-state kinetics, and isotope effects. Modern methods of computer analysis using non-linear least squares fitting and simulation to analyze binding isotherms and full kinetic time courses is emphasized. Prerequisite, physical chemistry, biochemistry, calculus, and organic chemistry. 3 class hours per week.
Student presentation of molecular biophysics topic. Second year students present from literature; senior students give formal research seminar. Attendance required for all molecular biophysics students.
Multi-laboratory research colloquia for DBBS graduate students focused on structural biology and complementary biophysical techniques. Course credit requires student presentation for credit.
This course covers a combination of classic and recent publications on computational methods for studying biomolecules. Students participating for credit will be required to present at least once.
Analysis of a selected set of key processes in development, such as pattern formation, cell-cell signaling, morphogenesis, etc. The focus is on molecular approaches applied to important model systems, but framed in classical concepts. The discussion section provides instruction in presenting a journal club and writing a research proposal. Prerequisites, Molecular Cell Biology (Bio 5068) and Nucleic Acids (548).
Course is devoted to studying microorganisms, particularly those that cause disease, with an emphasis on the molecular interactions between pathogens and hosts. First third of the course focuses on virology, second third on bacteriology and the last third on eukaryotic pathogens. Prereq, first semester core curriculum for Programs in Cell and Molecular Biology.
Graduate level seminar course focusing on current scientific literature in molecular parasitology. The journal club will meet biweekly during the Fall and Spring semesters. Students will attend both semesters in order to receive one credit. The seminar series will run jointly with a research conference in Tropical and Molecular Parasitology. Outside speakers will be invited for the seminar series to emphasize important developments in tropical medicine and molecular parasitology. In advance of the invited speakers, topics will focus on their previous research publications. Prerequisites, BIO 5392 Molecular Microbiology & Pathogenesis.
Presentations by students on a broad range of topics of current interest in microbiology and pathogenesis including areas of research in bacteriology, mycology, parasitology, virology and immunology. The course will emphasize techniques used to give good presentations and scientific critique. Speakers provide a brief background to introduce the topic and then focus on one-two papers from the current literature. Credit requires attendance at all sessions and one presentation.
This journal club covers a broad range of topics of current interest, including the fields of biochemistry, molecular biology, cell biology, developmental biology and immunology. Speakers usually give a brief background to introduce the topic and then focus on one-two papers from the current literature. Presentations are given by graduate students, post-doctorates and faculty. Each attendee presents two-three times per year. Participants are expected to attend all the sessions. This journal club was founded in 1966.
This course provides an opportunity for students, postdoctoral fellows, infectious disease fellows and faculty to explore issues at the interface between patient care, public health and basic research in the area of microbial pathogenesis. Prerequisites, Application and L41 Bio 5392 or M30 526, or permission of instructor.
Presentation of current research papers in DNA replication, DNA repair, and DNA recombination, with an emphasis on basic biochemical and biophysical approaches.
Student presentations of thesis research. Formal presentations require powerpoint. Required of all Biochemistry graduate students; first and second year students get credit.
This journal club is intended for beginning graduate students, advanced undergraduates, and MSTP students with a background in the quantitative sciences (engineering, physics, math, chemistry, etc). The subjects covered are inherently multidisciplinary. We will review landmark and recent publications in quantitative cardiovascular physiology, mathematical modeling of physiologic systems and related topics such as chaos theory and nonlinear dynamics of biological systems. Familiarity with calculus, differential equations, and basic engineering/thermodynamic principles is assumed. Knowledge of anatomy/physiology is optional.
This graduate course (seniors welcome) will cover the basic physics involved in creating an image by magnetic resonance technology. The use of this technology, specifically as it applies to the unique challenges of cardiovascular applications, will be examined. This will include topics such as motion compensation techniques, real-time imaging, exogenous contrast enhancement, and quantitative flow measurements, for example. As much as one-third of the class will involve actual case studies and the discussion of clinical use for cardiovascular MRI. Students will demonstrate competence in the subject through a combination of homework, a final examination, and a small semester project. Prereqs: Calculus, introductory human physiology/anatomy/biology course.
Students will present a research paper (or present their current thesis research) and the appropriate background material.
This course is designed for beginning students who want to become familiar with the basic concepts and applications of genomics. The course covers a wide range of topics including how genomes are mapped and sequenced as well as the latest computational and experimental techniques for predicting genes, splice sites, and promoter elements. High throughput techniques for ascribing function to DNA, RNA, and protein sequences including microarrays, mass spectrometry, interspecies genome comparisons and genome-wide knock-out collections will also be discussed. Finally, the use of genomic techniques and resources for studies of human disease will be discussed. A heavy emphasis will be put on students acquiring the basic skills needed to navigate databases that archive sequence data, expression data and other types of genome-wide data. Through problem sets the students will learn to manipulate and analyze the large data sets that accompany genomic analyses by writing simple computer scripts. While students will become sophisticated users of computational tools and databases, programming and the theory behind it are covered elsewhere, in Michael Brent's class, Bio 5495 Computational Molecular Biology. Because of limited space in our teaching lab, enrollment for lab credit will be limited to 24 students. Priority will be given to students in the DBBS program. Others interested in the course may enroll for the lectures only. If you have previous experience in computer programming, we ask that you do not enroll for the laboratory credit. Prerequisites, Molecular Cell Biology (Bio 5068), Nucleic Acids (Bio 548) or by permission of instructor. Lecture 3 units of credit; lab 1 additional unit, space limited.
In this biweekly journal club on Human Genetics we will present and discuss current cutting edge papers in human and mammalian molecular genetics. Students learn presentation skills, how to critique a paper and how to interact with a very active and critical audience. Prerequisites; Any person interested in the current state of the art in Human Genetics may attend this course. It is a requirement that all students wishing to earn credit in this course must present a 1.5 hour journal club talk and must regularly attend and participate in the journal club throughout the year.
Fundamental aspects of organismal genetics with emphasis on experimental studies that have contributed to the molecular analysis of complex biological problems. Examples drawn from bacteria, yeast, nematodes, fruit flies and mammalian systems. Prerequisite, graduate standing or permission of instructor.
Students present current research papers and the appropriate background material in the field of Computational Biology. **Arts and Sciences students must take this course for credit; Engineering students must take this course Pass/Fail.**
A significant portion of the first-year course in basic medical genetics devoted to human and clinical genetics, with emphasis on how genomic information will transform the practice of medicine. Topics covered include population genetics; molecular basis of mutations; human functional genomics; mouse models of human disease; pharmacogenomics; metabolic defects. Lectures, small group discussions, patient information session. Prereq, an introductory genetics course and permission of the instructor.
Classes will consider the molecular basis of the disease as well as animal models and current clinical studies. Addressing studies from the level of basic biophysical and molecular properties of the underlying ion channels/transporters, to the cellular deflects, to organ and animal outcomes and therapies., which will encourage and force sutdents to develop their ability to integrate understanding at multiple levels. Students will be introduced to emerging ideas in clinical diagnosis, management and treatment, when appropriate, clinical specialists will allow student participants to directly observe and participate in the clinical experiences. Prerequisites, Bio 5068 Fundamentals of Molecular Cell Biology.
An integrated course dealing with the structure, function and development of the nervous system. The course will be offered in the late Spring of the first year Medical School calendar. Prerequisite: Biol 3411 or Biol 501 and approval of the instructor.
Practical course on how to prepare and present scientific data to an audience. Prerequisite: First year neuroscience program courses. Meets once a week for 90 minutes.
Synaptic function and malleability are fundamental to nervous sytem function and disease. This is an advanced seminar in the development, structure, and function of the synapse in health and disease. It is a natural extension of topics covered in Bio 5571. It may be primarily of interest to students in the Neurosciences Program, but also to students in MCB, Development, Biochemistry, Computational Biology, and Molecular Biophysics. Generally a topic for the semester helps focus the group; past topics have included Synapses and Disease, Neurotransmitter Transporters, Glutamate Receptors, Dendrites, GABA receptors. Participants (students, postdocs, and faculty) alternate responsibility for leading critical discussion of a current paper. Active participation offers the opportunity for students to hone their critical thinking and presentation skills. Students enrolling for credit will be expected to attend each week, to lead discussion once per semester and to provide written critiques (1-2 pages each) of two papers. Prerequisites, Graduate standing in DBBS; Bio 5571 preferred.
The goal of this course is to help students in the CCSN Pathway develop the critical thinking skills necessary to develop and implement high quality, interdisciplinary research projects. Throughout the course of the semester, each student will develop a research plan in their chosen area of interest. The plan will be developed in consultation with at least two faculty members (from at least two different subdisciplines within the pathway) as well as the other students and faculty participating in the course. The culmination of this course will be for each student to produce an NIH-style grant proposal on the research project of their choosing. For most students, this will serve either as their thesis proposal or a solid precursor to the thesis proposal. The course will be designed to help facilitate the development of such a research plan through didactic work, class presentations, class discussion, and constructive feedback on written work. The course will begin with a review of written examples of outstanding research proposals, primarily in the form of grant submissions similar to those that the students are expected to develop (i.e., NRSA style proposals, R03 proposals). Review of these proposals will serve as a stimulus to promote discussion about the critical elements of good research proposals and designs in different areas. Each student will be expected to give three presentations throughout the semester that will provide opportunities to receive constructive feedback on the development and implementation of research aims. The first presentation (towards the beginning of the semester) will involve presentation of the student's general topic of interest and preliminary formulation of research questions. Feedback will emphasize ways to focus and develop the research hypotheses into well-formulated questions and experiments. The second presentation will involve a more detailed presentation of specific research questions (along the lines of NIH-style Sp
This course will provide a two-part introduction to Neuroscience Research fundamentals. Namely, it will introduce elementary statistical analysis for Neuroscience research and an introduction for grant-writing to support Neuroscience-related research. Prerequisite, limited to first year neuroscience students.
The course will consist of lectures and discussions of the sensory, motor and integrative systems of the brain and spinal cord, together with a weekly lab. The lectures will present aspects of most neural systems, and will be given by faculty members who have specific expertise on each topic. The discussions will include faculty led group discussions and papers presented and discussed by students. The labs will include human brain dissections, examination of histological slides, physiological recordings, behavioral methods, computational modeling, and functional neural imaging.
This course will consider the computations performed by the biological nervous system with a particular focus on neural circuits and population-level encoding/decoding. Topics include, Hodgkin-Huxley equations, phase-plane analysis, reduction of Hodgkin-Huxley equations, models of neural circuits, plasticity and learning, and pattern recognition & machine learning algorithms for analyzing neural data. Note: Graduate students in psychology or neuroscience who are in the Cognitive, Computational, and Systems Neuroscience curriculum pathway may register in L41 5657 for three credits. For non-BME majors, conceptual understanding, and selection/application of right neural data analysis technique will be stressed. Hence homework assignments/examinations for the two sections will be different, however all students are required to participate in a semester long independent project as part of the course. Calculus, Differential Equations, Basic Probability and Linear Algebra Undergraduates need permission of the instructor. L41 5657 prerequisites: Permission from the instructor
Clocksclub focuses on recent advances in the study of biological timing including sleep and circadian rhythms. Participants discuss new publications and data on the molecules, cells and circuits underlying daily rhythms and their synchronization to the local environment. Students registered for this journal club will lead a discussion once during the semester. Prerequisites: BIO 2970 or permission of instructor.
This weekly seminar, covering different topics each semester, should be taken by graduate students in the program. Prerequisite, graduate standing or permission of instructor.
Students in this journal club will meet weekly with ethnobotanists, ethnozoologists, and ecologists from various St. Louis institutions (including Washington University, UM-St. Louis, St. Louis University, and the Missouri Botanical Garden) to discuss recent publications and ongoing research. Enrolled students will attend the journal club every week, and once per semester, will choose a paper and lead the discussion. Course meets in the 3rd floor conference room of the Monsanto Bldg. at the Missouri Botanical Garden. Transportation from campus can be provided.
This weekly seminar provides an introduction to/overview of Plants, each semester progressively covering orders and families in a sequence derived from the Angiosperm Phylogeny Website (http://www.mobot.org/MOBOT/Research/APweb/welcome.html); in Spring 2015, the seminar will cover several crown orders of the monocots, including grasses and relatives. Weekly presentations include a summary of all relevant information (molecular, chemical, anatomical, embryological, morphological, ecological, geographical, historical/paleontological, etc.) about the plant group under consideration, review of the classification/phylogeny of the group, examination of fresh and/or preserved specimens, and discussion of relationships, human uses, and other relevant aspects of the biology of that group. Credit will be contingent on one (or two) seminar presentation(s) per student, regular attendance and active participation in group discussions.
This is a weekly discussion seminar course in which advanced graduate students and postdocs in STEM will discuss the practices of scientific teaching and basic professional development skills. Topics covered will include scientific teaching, active learning, assessment driven instruction, creation inclusive classrooms, preparing for job interviews, preparing grant proposals, and balancing family and work. There will be several panel discussions with invited speakers on a range of potential career options to STEM PhDs. Students will prepare or revise their professional portfolio materials over the course of the semester. The course is open to all DBBS graduate students and is required for GAANN fellows. Prerequisite: Graduate student status in the DBBS or permission of instructor.
Credit to be arranged.
In this course, advanced graduate students and postdocs in STEM will 1) learn the fundamentals of the Scholarship of Teaching and Learning (SoTL)-which is the practice of developing, reflecting on, and evaluating teaching methods to improve student learning, 2) Develop a working knowledge of SoTL, which draws on research in education, STEM education, and cognitive science, 3) Understand how SoTL can lead to the dissemination of new knowledge to a broad audience of educators through publication and presentations., and 4) Develop the central elements of a SoTL project. These elements include articulating questions about classroom teaching that can be addressed in a SoTL research project; developing working hypotheses in response to the questions; designing an evaluative plan, including specific research methods, the type of data to be collected, and how the data will be analyzed in relation to the hypotheses; identifying and understanding necessary procedures to obtain IRB approval for the research. Prereqs: Must be an advanced graduate student or a postdoctoral appointee with some teaching experience, and must have completed 4 STEM Pedagogies workshops (2 are foundational topics) offered by The Teaching Center or received approval from one of the instructors. Same as U29 Bio 4902.
Credit to be arranged.
Credit to be arranged.
Credit to be arranged.
This project-based (MATLAB) class will introduce several current techniques for systems-level measurement of molecules and a set of computational techniques for inferring biological meaning from such experiments. Several molecular types and measurement techniques will be covered. How to determine the quality of measurements will lay the groundwork for understanding a new measurement technique. From there, computational topics will include dimensionality reduction techniques, correlations between measurements and outcomes, and network modeling and inference. A working knowledge of molecular biology, differential equations, linear algebra, and statistics is required.
Students serve as teaching assistants for undergraduate and graduate level courses. Faculty-supervised activities include: lecture preparation and presentation; leading discussion and problem-solving sessions; laboratory instruction. Prequisite, restricted to graduate students in the Division of Biology and Biomedical Sciences.
This course is a series of facilitated discussions aimed at developing and improving mentoring skills for those involved in supervising undergraduate research experiences. It is designed for postdocs and graduate students who are or will be ´bench mentors´ for undergraduates doing Bio 500 and/or Summer Research. Participants will receive "Entering Mentoring" materials, including articles and worksheets to facilitate mentoring interactions with their mentee, plus several resource books relevant to mentoring. They will develop a mentoring philosophy statement, work on specific assignments designed to improve their relationship with their mentee and share their present and past experiences as mentors and mentees. Bench mentors will be eligible for a travel award to help defray expenses for attending a meeting with their mentee, if that student wins one of the HHMI SURF travel awards (4-5 awarded annually) or is otherwise being supported to present at a scientific meeting. Prerequisite: open to graduate students and postdocs, with priority for those who plan to mentor undergraduates in summer research experiences. Graduate students and postdocs do NOT need to be mentoring a student at the time of the course; it is open to all with an interest in mentoring now or in the future. Note: The sessions will be held either at the beginning of the day or the end of the day at the Danforth campus. Once registration closes, an email will be sent to those registered to poll for the best days & times.
This course is designed for individual students wishing to explore indepth specialized areas of literature or technology with one or more faculty members. Credit will vary with the amount of work and discussion, but cannot be more than 3 credits.