DBBS graduate programs Plant and Microbial Biosciences Program
Molecular Genetics and Genomics Program
Computational and Systems Biology Program
Our lab studies microbial metabolisms and their influence on biogeochemical cycling using an interdisciplinary approach. We apply the knowledge we gain to generate new ways of addressing issues such as the energy crisis, pollution, biofouling and sustainability.
First things first - this is a microbial world
This statement is absolutely correct in so many ways. The fact that our bodies have way more microbial cells than human cells might hit home the most. Microbes existed way before our ancestors appeared on this planet. They can perform many interesting microbial metabolisms. These microbial capabilities might appear strange and exotic to us mostly because we think of our planet as being the same as it is now. But our planet is always evolving; it has seen things that we can't imagine. Our planet's oldest friends are microbes and they have co-evolved. On today's Earth we see sneak peeks of this ancient and on going friendship in places that resemble its older forms such as in Yellowstone National Park (see left Mammoth Hot Springs with thick microbial mats, Summer 2014). Using geochemical & molecular tools along with -omic information we are starting to predict how microbes are shaping our planet today, and also shedding light on what they might have been doing in the past.
Caption: Mammoth Hot Springs microbial mats, Summer 2014
Some of the broad questions we strive to answer are:
- What is the genetic and molecular basis of a specific microbial metabolism? (Genetics, Biochemistry and Molecular Biology)
- How are these genes regulated in bacteria and archaea? (Gene Regulation)
- Can environmental microbes be used to help us come up with sustainable solutions to the energy crisis and climate change? (Synthetic Biology and Metabolic Engineering)
- Can we use these genes are markers for a specific microbial metabolism in nature? How does microbial physiology determine the distribution of microbes? How do microbes continue to shape our planet? (Microbial Ecology, Geomicrobiology and Earth History)
For detailed project information please visit the lab website.
Bose A, Gardel EJ, Vidoudez C, Parra EA, Girguis PR (2014). Electron uptake by iron oxidizing phototrophic bacteria. Nat. Commun. 5, Article number:3391. Featured in Science Daily, EurekAlert and various news articles & blogs. Contact me to get PDF for personal use only.
Bose A, Rogers DR, Adams MM, Joye SB, Girguis PR (2013). Geomicrobiological linkages between short-chain alkane consumption and sulfate reduction rates in seep sediments. Front. Microbiol. 4:386.Featured in The Gulf of Mexico Research Initiative. Open access.
Adams, MM, Hoarfrost AL, Bose A, Joye SB, Girguis PR (2013). Anaerobic oxidation of short-chain alkanes in hydrothermal sediment: influences on sulfur cycling and microbial diversity. Front. Microbiol. 4:110. Open access.
Bose A, Newman, DK. (2011) Regulation of the phototrophic iron oxidation (pio) genes in Rhodopseudomonas palustris TIE-1 is mediated by the global regulator, FixK. Mol Microbiol. 79(1):63-75. Open access.
Bose A, Kopf S, Newman, DK. (2010) From geocycles to genomes and back. In Stolz JF and Oremland, RS (ed.), Microbial metal and metalloid metabolism. ASM press, Washington, D.C. Featured in Microbe (2012) 7(5):246-247. Available at ASM Press.
Bose A, Kulkarni G, Metcalf WW. (2009) Regulation of putative methyl-sulfide methyltransferases in Methanosarcina acetivorans C2A. Mol Microbiol. 74(1):227-38. Open access.
Opulencia RO, Bose A, Metcalf WW. (2009) Physiology and post-transcriptional regulation of methanol:coenzyme M methyltransferase isozymes in Methanosarcina acetivorans C2A. J Bacteriol. 191(22):6928-35. Open access.
Bose A. Genetic and biochemical analysis of methyltransferase gene regulation in Methanosarcina acetivorans C2A. PhD Thesis,University of Illinois at Urbana-Champaign. Available at Proquest LLC.
Bose A, Pritchett MA, Metcalf WW (2008) Genetic analysis of the methanol specific methyltransferase 2 genes of Methanosarcina acetivorans C2A. J Bacteriol. 190(11):4017-26. Open access.
Bose A, Metcalf WW (2008). Distinct regulators control the expression of methanol methyltransferase isozymes in Methanosarcina acetivorans C2A. Mol Microbiol. 67(3):649–61. Open access.
Bose A, Pritchett MA, Rother M, Metcalf WW.(2006) Differential regulation of the three methanol methyltransferase isozymes in Methanosarcina acetivorans C2A. J Bacteriol. 88(20):7274-83. Open access.
Bose A, Sharma D, Shakila H, Das TK, TyagiJS, Ramanathan VD. (2006) Expression of mycobacterial cell division protein, FtsZ, and dormancy proteins, DevR and Acr, within lung granulomas throughout guinea pig infection. FEMS Immunol Med Microbiol. 48(3):329-36. Open access.
Rother M, Boccazzi P, Bose A, Pritchett MA, Metcalf WW.(2005) Methanol-dependent gene expression demonstrates that methyl-coenzyme M reductase is essential in Methanosarcina acetivorans C2A and allows isolation of mutants with defects in regulation of the methanol utilization pathway. J Bacteriol. 187(16):5552-59. Open access.